GM1 ganglioside enhances synaptosomal resistance to chemically induced damage

GM1 ganglioside enhances synaptosomal resistance to chemically induced damage.

A neurotoxic agent, chlordecone, damages the limiting membrane of isolated synaptosomes prepared from rat brain. This is shown by increased levels of free, ionic calcium and increased permeability of synaptosomes, using the fluorimetric probe, fura-2. Pretreatment of synaptosomes with the monosialoganglioside GM1, attenuates the effect of chlordecone. A parallel preincubation of synaptosomes wi...

Prevention of chemically induced changes in synaptosomal membrane order by ganglioside GM1 and alpha-tocopherol.

Synaptosomal membrane order has been studied by analysis of light depolarization by fluorescent dyes intercalated within membranes following exposure to various environmental toxicants. Two probes were explored: 1,6-diphenyl-1,3,5-hexatriene (DPH), signaling predominantly from the lipid-rich membrane core, and 1-[4-(trimethylamino)phenyl]-6-phenyl-1,3,5-hexatriene (TMA-DPH), reporting from the ...

Ganglioside GM1 reduces white matter damage in neonatal rats.

This study investigated the neuronal protective effect of monosialotetrahexosylganglioside (GM1) on the hypoxia-ischemia white matter damage (WMD) in neonatal rats. Brain hypoxia-ischemia was induced by bilateral carotid artery occlusion in 4-day-old neonatal rats. Bilateral carotid artery occlusion (BCAO) was performed in rats in WMD and GM1 groups, while in sham group; the rat bilateral carot...

GM1 Ganglioside Inhibits β‐Amyloid Oligomerization Induced by Sphingomyelin

β-Amyloid (Aβ) oligomers are neurotoxic and implicated in Alzheimer's disease. Neuronal plasma membranes may mediate formation of Aβ oligomers in vivo. Membrane components sphingomyelin and GM1 have been shown to promote aggregation of Aβ; however, these studies were performed under extreme, non-physiological conditions. We demonstrate that physiological levels of GM1 , organized in nanodomains...

GM1 ganglioside therapy in acute ischemic stroke.